Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :ENMD-2076 Tartrate1291074-87-7HY-10987525.56C25H31N7O6>98%Solubility:DMSOMechanisms: Pathways:Cell Cycle/DNA Damage; Target:Aurora Kinase gyBiological Activity:ENMD-2076 is a antiangiogenic and Aurora kinase inhibitor with IC50 of 3, 13, 350, 23, 40, 93 and120 nM for Flt-3, AurA, AurB, Src, KDR/VEGFR2 and FGFR1.References:[1]. Matulonis UA, Lee J, Lasonde B, Tew WP, Yehwalashet A, Matei D, Behbakht K, Grothusen J,Fleming G, Lee NK, Arnott J, Bray MR, Fletcher G, Brokx RD, Castonguay V, Mackay H, Sidor CF,Oza AM.ENMD-2076, an oral inhibitor of angiogenic and proliferation kinases, has activity inrecurrent, platinum resistant ovarian cancer.Eur J Cancer. 2012pAug 21.g[2]. How J, Yee K.ENMD-2076 for hematological malignancies.Expert Opin Investig Drugs. 2012May;21(5):717-32. Epub 2012 Mar 8. [3]. Zhang S, Farag SS.From cell biology to therapy: ENMD-2076 in the treatment of multiplemyeloma.Expert Opin Investig Drugs. 2011 Jul;20(7):1015-28. Epub 2011 May 26. [4]. Fletcher GC, Brokx RD, Denny TA, Hembrough TA, Plum SM, Fogler WE, Sidor CF, BrayMR.ENMD-2076 is an orally active kinase inhibitor with antiangiogenic and antiproliferativemechanisms of action.Mol Cancer Ther. ...Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com18Wilkinson Way, Princeton, NJ 08540,USAEmail: info@medchemexpress.com Web: www.medchemexpress.com