专利名称：Production of polyhydroxyalkanoates from
polyols
发明人：Frank A. Skraly,Martha Sholl申请号：US12539079申请日：20090811公开号：US08741624B2公开日：20140603
摘要：Recombinant processes are provided whereby additional genes are introducedinto which have been genetically engineered to produce PHA so that the improvedstrains produce PHA homopolymers and copolymers directly from diols. In preferredembodiments, PHAs containing 4-hydroxybutyrate monomers are produced directlyfrom 1,4-butanediol; PHAs containing 5-hydroxyvalerate are produced from 1,5-pentanediol; PHAs containing 6-hydroxyhexanoate (6HH) are produced from 1,6-hexanediol; PHAs containing 3-hydroxypropionate are produced from 1,3-propanediol;PHAs containing 2-hydroxypropionate (lactate) are produced from 1,2-propanediol(propylene glycol); PHAs containing 2-hydroxyethanoate (glycolate) are produced from1,2-ethanediol (ethylene glycol). Genes encoding these same enzyme activities can beintroduced or their expression amplified in wild type PHA producers to improve theproduction of PHA homopolymers and copolymers directly from diol and other alcoholfeedstocks. The PHA polymers are readily recovered and industrially useful as polymersor as starting materials for a range of chemical intermediates.
申请人：Frank A. Skraly,Martha Sholl
地址：Watertown MA US,Haverhill MA US
国籍：US,US
代理机构：Pabst Patent Group LLP
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