专利名称：PRODUCTION OF
POLYHYDROXYALKANOATES FROMPOLYOLS
发明人：SKARLY, Frank, A.,SHOLL, Martha申请号：EP01953560.8申请日：20010720公开号：EP1305439A2公开日：20030502
摘要：Recombinant processes are provided whereby additional gens are introducedinto E.coli which have been genetically engineered to produce PHA so that the improvedstrains produce PHA homopolymers and copolymers directly from diols. In preferredembodiments, PHAs containing 4-hydroxybutyrate monomers are produced direcltyfrom 1,4-butanediol; PHAs containing 5-hydroxyvalerate are produced from 1,5-pentanediol; PHAs containing 6-hydroxyhexanoate (6HH) are produced from 1,3-propanediol; PHAs containing 3-hydroxypropionate are produced from 1,3-propanediol;PHAs containing 2-hydroxypropionate are produced from 1,3-propanediol; PHAscontaining 2-hydroxypropionate (lactate) are produced from 1,2-propanediol (propyleneglycol; PHAs containing 2-hydroxyethanoate (glycolate) are produced from 1,2-ethanediol (ethylene glycol). Genes encoding these same enzyme activities can beintroduced or their expression amplified in wild type PHA producers to improve theproduction of PHA homopolymers and copolymers directly from diol and other alcoholfeedstocks. The PHA polymers are readily recovered and industrially useful as polymersor as starting materials for a range of chemical itnermediates.
申请人：METABOLIX, INC.
地址：2nd Floor,303 Third Street Cambridge, MA 02142-1196 US
国籍：US
代理机构：Bassett, Richard Simon
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