GENETICALLY MODIFIED YT CELL LINE AND USE THEREOF

专利名称：GENETICALLY MODIFIED YT CELL LINE AND

USE THEREOF

发明人：PECHER, GABRIELE申请号：DE0201437申请日：20020418公开号：WO02088336A3公开日：20030403

摘要：The invention relates to a YT cell line, modified by genetic engineering, intowhich the genes of receptors are introduced and which is suitable for treating tumours,tumour metastases, virus infections, for cleaning (purging) blood stem cell preparationsand also for diagnostic purposes. Areas of application include the medical field and thepharmaceutical industry. The aim of the invention is to identify tumour cells and othertarget cells by means of the gene transfer of specific receptors into the YT cell line. Anadditional aim is to cause a lysis of the identified tumour cells and other target cells,using the newly created cell line. The inventive cell line contains one or more receptors(consisting of variable regions of tumour-specific or target cell specific antibodies (singlechain Fv fragments)) and optionally a signal chain, which is derived from the zeta-chain ofthe human T-cell receptor.

申请人：PECHER, GABRIELE

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