专利名称：Protein sequences of serrate gene products发明人：David Ish-Horowicz,Domingos Manuel Pinto
Henrique,Julian Hart Lewis,Anna MaryMyat,Robert J. Fleming,Spyridon Artavanis-Tsakonas,Robert S. Mann,Grace E. Gray
申请号：US08/611729申请日：19960306公开号：US06004924A公开日：19991221
摘要：The present invention relates to nucleotide sequences of Serrate genes, andamino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments)and analogs thereof. In a specific embodiment, the Serrate protein is a human protein.The invention further relates to fragments (and derivatives and analogs thereof) ofSerrate which comprise one or more domains of the Serrate protein, including but notlimited to the intracellular domain, extracellular domain, DSL domain, cysteine richdomain, transmembrane region, membrane- associated region, or one or more EGF-likerepeats of a Serrate protein, or any combination of the foregoing. Antibodies to Serrate,its derivatives and analogs, are additionally provided. Methods of production of theSerrate proteins, derivatives and analogs, e.g., by recombinant means, are also provided.Therapeutic and diagnostic methods and pharmaceutical compositions are provided. Inspecific examples, isolated Serrate genes, from Drosophila, chick, mouse, Xenopus andhuman, are provided.
申请人：IMPERIAL CANCER RESEARCH TECHNOLOGY, LTD.,YALE UNIVERSITY
代理机构：Pennie & Edmonds LLP
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