脐血干细胞移植与神经生长因子联合治疗小儿脑性瘫痪的安全性分析

李 迎

天津红桥医院儿科，天津市 300130

Safety analysis of umbilical cord blood stem cell

transplantation combined with nerve growth factor in the treatment of cerebral palsy in children

Li Ying

Department of Pediatrics, Hongqiao Hospital of Tianjin, Tianjin 300130, China 摘要

背景：脐血干细胞移植联合神经生长因子治疗小儿脑性瘫痪是临床研究热点。 目的：分析脐血干细胞移植联合神经生长因子治疗小儿脑性瘫痪疗效及安全性。

方法：选取天津红桥医院儿科2011年11月至2013年2月收治的脑性瘫痪患儿80例，按治疗方法分别分为试验组(n=40)和对照组(n=40)，分别接受脐血干细胞移植与神经生长因子联合治疗和单独神经生长因子治疗。

结果与结论：与治疗前相比，2组患儿治疗后脑性瘫痪综合功能评定表及粗大运动功能测量量表分值均有所提高(P < 0.05)，且白细胞计数、中性粒细胞分数、总胆红素、丙氨酸氨基转移酶、天冬氨酸氨基转移酶明显升高(P < 0.05)，且试验组患儿的治疗效果优于对照组(P < 0.05)。所有患儿未见严重不良反应。说明脐血干细胞移植联合神经生长因子治疗小儿重症脑性瘫痪疗效显著，安全性高。

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

全文链接：

关键词 ： 干细胞； 脐带脐血干细胞； 神经生长因子； 脑性瘫痪； 安全性； 综合功能评定； 血

常规； 肝肾功能； 不良反应；

Abstract：

BACKGROUND: Umbilical cord blood stem cell transplantation combined with nerve growth factor in the treatment of children with cerebral palsy is a clinical hotspot.

OBJECTIVE: To analyze the efficacy and safety of umbilical cord blood stem cell transplantation combined with nerve growth factor in the treatment of cerebral palsy in children.

METHODS: A total of 80 children with cerebral palsy admitted at the Department of Pediatrics, Hongqiao Hospital of Tianjin, China from 2011 November to 2013

February were enrolled, and according to therapeutic methods, they were divided into experimental group (n=40; treated with umbilical cord blood stem cell transplantation combined with nerve growth factor) and control group (n=40; treated with nerve growth factor alone).

RESULTS AND CONCLUSION: After treatment, scores on comprehensive function assessment scale and gross motor function measure scale were significantly increased in the two groups (P < 0.05), while white cell count, neutrophil fraction, and levels of total bilirubin, alanine aminotransferase and aspartate aminotransferase were also increased (P < 0.05). Moreover, the experimental group showed a better outcome than the control group after treatment (P < 0.05). All of the patients had no serious adverse reactions. Umbilical cord blood stem cell transplantation combined with nerve growth factor has dramatic curative effects in children with severe cerebral palsy significant curative effect, with high safety.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

全文链接：

Key words： cerebral palsy; cord blood stem cell transplantation; nerve growth factor;

comparative effectiveness research ;

中图分类号: R394.2

作者简介: 李迎，女，1966年生，天津市人，汉族，1991年天津第二医学院毕业，主治医师，主要从事儿内科临床研究。

引用本文:

李 迎. 脐血干细胞移植与神经生长因子联合治疗小儿脑性瘫痪的安全性分析[J]. 中国组织工程研究, 2014, 18(28): 4588-4592.

Li Ying. Safety analysis of umbilical cord blood stem cell transplantation combined with nerve growth factor in the treatment of cerebral palsy in children[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(28): 4588-4592.