专利名称：T CELL EPITOPES OF RYEGRASS POLLEN
ALLERGEN.
发明人：KNOX, ROBERT, BRUCE,SINGH, MOHAN,
BIR,ROLLAND, JENNIFER,BLAHER,BELLA,SUPHIOGLU,CENK,MCCLUSKEY,JAMES
申请号：EP93917452申请日：19930813公开号：EP0656012A4公开日：19970423
摘要：The present invention provides isolated peptides of Lol p V, a major proteinallergen of the species Lolium perenne. Therapeutic peptides within the scope of theinvention comprise at least on T cell epitope, or preferably at least two T cell epitopes ofa protein allergen of Lol p V. Diagnostic peptides within the scope of the invention bindIgE. The invention also provides modified peptides having similar or enhanced therapeuticproperties as the corresponding, naturally-occurring allergen or portion thereof, buthaving reduced side effects. The invention further provides nucleic acid sequences codingfor peptides of the invention. Methods of treatment or diagnosis of sensitivity to Lol p Vor an allergen immunologically related to Lol p V in an individual. Therapeuticcompositions comprising one or more peptides of the invention are also provided.
申请人：THE UNIVERSITY OF MELBOURNE
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